Soluble Tag-Assisted Peptide Head-to-Tail Cyclization
Soluble Tag-Assisted Peptide Head-to-Tail Cyclization: Total Synthesis of Mahafacyclin B
Y Fujita, S Fujita, Y Okada, K Chiba, Org. Lett., 2013, Article ASAP
DOI: 10.1021/ol4003477
Publication Date (Web): March 5, 2013
Copyright © 2013 American Chemical Society
A soluble tag-assisted liquid-phase method was successfully applied to peptide head-to-tail cyclization, leading to the total synthesis of antimalarial cyclic heptapeptide, mahafacyclin B (1). The cyclization was carried out in the liquid phase with the tag remaining, which allowed rapid reaction workup and product isolation.
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